DENTAL PULP TISSUE IS ROUTINELY EXPOSED TO MANY IRRITANT SUCH AS CARIES AND TRAUMA. CLINICALLY, WHEN PULP IS DIAGNOSED IRREVERSIBLE PULPITIS, NO TREATMENT CAN REVERSE THE SITUATION REGARDLESS THE AMOUNT OF THE REMAINING NORMAL PULP TISSUE AND THE DAMAGED PULP TISSUE SHOULD BE REMOVED.SINCE PULP TISSUE POTENTIALLY CONTAIN MANY TYPE OF STEM CELL, WHICH CAN REVERSE TO PULPAL CELLS, REGENERATIVE PROCEDURES SUCH AS PARTIAL AND TOTAL PULPOTOMY RECOMMENDED TO REPLACE DAMAGED PULP TISSUE. THREE MAIN FACTORS IN REGENERATIVE ENDODONTIC ARE AS FOLLOWS: STEM CELL, GROWTH FACTOR AND SCAFFOLD. DENTAL PULP STEM CELLS (DPSCS), STEM CELLS FROM EXFOLIATED DECIDUOUS TEETH (SHED), PERIODONTAL LIGAMENT STEM CELLS AND STEM CELLS FROM APICAL PAPILLA (SCAP) HAVE BEEN ISOLATED AND CHARACTERIZED AS PROGENITOR OF PULP CELLS. THE MAIN GOAL OF REGENERATION IS VITAL PULP PROTECTION WITH EITHER PARTIAL OR TOTAL PULPOTOMY. IN THE CASE OF PULP NECROSIS WITH OPEN APICES, REGENERATION USING PERIODONTAL STEM CELLS SHOULD BE DONE WHEN ANY OTHER PROCEDURE SUCH AS CONVENTIONAL ROOT CANAL THERAPY OR APICAL PLUG ARE CONTRAINDICATED.NEW APPROACHES IN THESE CONCEPTS WILL BE DISCUSSED IN LECTURE PRESENTATION.